Short Term Treatments for Depression: Ketamine vs. ECT
While electroconvulsive therapy (ECT) and ketamine are both effective treatments for depression, ketamine was found to have a faster onset of action and better short-term cognitive outcomes than ECT, according to study results published in the Journal of Psychiatric Research…read more
Sublingual Ketamine: An Option for Increasing Accessibility of Ketamine Treatments for Depression?
To the Editor: A recent review on oral ketamine for depression described an antidepressant effect that was delayed in the range of 2–6 weeks, as compared to the rapid action of intravenous (IV) ketamine treatment. This differs from our clinical experience using sublingual (SL) ketamine to treat patients with severely treatment-resistant depression (TRD). In our experience, SL ketamine can both provide and sustain rapid antidepressant effects. We suspect this difference may be a dose effect, and we wish to note that to determine appropriate dosing for future prospective studies, bioavailability of each formulation of ketamine must be considered….read more
Anti-depressant spray not recommended on NHS
A fast acting ketamine-like anti-depressant spray that can lift mood within hours has been rejected by the NHS healthcare watchdog.
The National Institute for Health and Care and Excellence (NICE) says there are too many uncertainties about the correlation between the price and clinical benefits of esketamine…read more
Ketamine Plus Motivational Enhancement Therapy: Leveraging a Rapid Effect to Promote Enduring Change
Problematic alcohol use and its sequelae are major causes of medical morbidity worldwide and leading contributors to excess mortality. Globally, the estimated 12-month and lifetime adult prevalence rates of alcohol use disorder are 8.5% and 20%, respectively, with even higher rates in the United States. Remarkably few individuals receive any treatment for alcohol use disorder, and even fewer receive evidence-based psychotherapeutic or pharmacological treatment…read more
The Complete Guide to Ketamine Therapy for Depression, From Someone Who’s Tried It
This piece is part of Allure’s Let’s Talk Therapy series.
When I entered the ketamine clinic for the first time, I started crying almost immediately. This was for two reasons: First and foremost, I was scared. After watching a documentary that introduced me to the subject and reading several accounts of ketamine infusion therapy, I knew a fair amount about the process. But the experience sounded strange, disorienting, and mysterious. Despite having done my research, I still didn’t feel like I had a good idea of exactly what it would feel like….read more
Ketamine Could Be the Key to Reversing America’s Rising Suicide Rate
By Cynthia Koons and Robert Langreth
A version of the club drug is expected to be approved for depression in March. Researchers think it could help treat suicidal thinking…read more
Ketamine Changes Course of Major Depressive Disorder Treatment
Currently, there is an unmet need for the development of rapid-acting antidepressants aimed at treatment-resistant patients with either major depressive disorder (MDD) or bipolar disorder. A review of existing treatment options, as well as future possibilities, was published in Psychiatry and Clinical Neurosciences…read more
CT Psychiatrist Shows Titrated IV Ketamine Can STOP Suicidality
SOUTH WINDSOR, Conn., Oct. 8, 2019 /PRNewswire/ — Lori Calabrese, M.D., Innovative Psychiatry (https://loricalabresemd.com). Local psychiatrist publishes data demonstrating that the use of a series of IV ketamine infusions, with dose adjustments, can stop suicidal thoughts and avert ER trips and hospitalizations. The research, published in the International Journal of Psychiatry Research, comprised a retrospective chart review of 231 patients with treatment resistant depression and co-occurring complex psychiatric illnesses treated in a large psychiatry office…read more